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Tg(CMV-HTT*48Q)BTag
Transgene Detail
Nomenclature
Symbol: Tg(CMV-HTT*48Q)BTag
Name: transgene insertion B, Danilo A Tagle
MGI ID: MGI:5569528
Synonyms: HD48B
Transgene: Tg(CMV-HTT*48Q)BTag  Location: unknown  
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(CMV-HTT*48Q)BTag expresses 1 gene
 
Mutation detailsThe full-length human huntingtin cDNA containing 48 CAG repeats is under the control of the cytomegalovirus promoter and SV40 enhancer. Three lines, B-D, were established. No CAG repeat instability was detected by PCR amplification. Western blot analysis confirmed transgene expression in the brain, including primary and secondary motor cortices, entorhinal cortex, striatum, hippocampus and cerebellum. Transgene expression in the brain is five times that of endogenous levels. (J:50173)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:50173 Reddy PH, et al., Behavioural abnormalities and selective neuronal loss in HD transgenic mice expressing mutated full-length HD cDNA. Nat Genet. 1998 Oct;20(2):198-202
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory