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Tg(Ins1-Cd80)378Psoh
Transgene Detail
Nomenclature
Symbol: Tg(Ins1-Cd80)378Psoh
Name: transgene insertion 378, Pamela Ohashi
MGI ID: MGI:5569013
Synonyms: B7-1, RIP-B7-1
Transgene: Tg(Ins1-Cd80)378Psoh  Location: unknown  
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Ins1-Cd80)378Psoh expresses 1 gene
 
Mutation detailsThe rat insulin 1 promoter drives the expression of the mouse Cd80 cDNA. Three lines were created: 340, 368, and 378. Immunostaining and Northern blot analysis confirmed expression on beta cells but not in other tissues. (J:209714)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:209714 Harlan DM, et al., Mice expressing both B7-1 and viral glycoprotein on pancreatic beta cells along with glycoprotein-specific transgenic T cells develop diabetes due to a breakdown of T-lymphocyte unresponsiveness. Proc Natl Acad Sci U S A. 1994 Apr 12;91(8):3137-41
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory