Usp21^tm1.1Jhy
Targeted Allele Detail

Summary

• Symbol: Usp21^tm1.1Jhy
• Name: ubiquitin specific peptidase 21; targeted mutation 1.1, Jianhua Yang
• MGI ID: MGI:5568976
• Synonyms: Usp21^-
• Gene: Usp21 Location: Chr1:171109523-171115534 bp, - strand Genetic Position: Chr1, 79.3 cM
• Alliance: Usp21^tm1.1Jhy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:208320
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Knockdown)
• Mutation: Intragenic deletion
• Mutation details: A loxP-FRT-neo-FRT-exon3/4-loxP cassette was inserted via homologous recombination. Cre-mediated recombination removed the neo cassette and exons 3 and 4. Western analysis confirmed the absence of protein in homozygous mutants. (J:208320)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Usp21 Mutation: 25 strains or lines available

References

• Original: J:208320 Fan Y, et al., USP21 negatively regulates antiviral response by acting as a RIG-I deubiquitinase. J Exp Med. 2014 Feb 10;211(2):313-28
• All: 1 reference(s)