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Mir205tm1.2Mtm
Targeted Allele Detail
Nomenclature
Symbol: Mir205tm1.2Mtm
Name: microRNA 205; targeted mutation 1.2, Michael McManus
MGI ID: MGI:5568716
Gene: Mir205  Location: Chr1:193507463-193507530 bp, - strand  Genetic Position: Chr1, 97.82 cM
Small size and skin defects in P10 Mir205tm1.2Mtm/Mir205tm1.2Mtm mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:209028
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector was designed to insert an FRT site followed by a lacZ gene, a loxP site, a neomycin cassette, an FRT site and a loxP site (FRT-lacZ-loxP-Neo-FRT-loxP) upstream of the microRNA stem loop and one loxP site immediately downstream of the microRNA stem loop. Flp-mediated recombination removed the reporter and selection cassettes. Cre-mediated recombination removed the microRNA sequence. (J:209028)
Generation of the Mir205tm1Mtm, Mir205tm1.1Mtm, and Mir205tm1.2Mtm alleles
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mir205 Mutation:  3 strains or lines available
References
Original:  J:209028 Farmer DT, et al., Partially penetrant postnatal lethality of an epithelial specific MicroRNA in a mouse knockout. PLoS One. 2013;8(10):e76634
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory