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Targeted Allele Detail
Symbol: Tlr4tm1.1Karp
Name: toll-like receptor 4; targeted mutation 1.1, Christopher Karp
MGI ID: MGI:5568597
Synonyms: TLR4fl
Gene: Tlr4  Location: Chr4:66827551-66846581 bp, + strand  Genetic Position: Chr4, 34.66 cM
Germline Transmission:  Earliest citation of germline transmission: J:101977
Parent Cell Line:  CMTI-2 (ES Cell)
Strain of Origin:  C57BL/6J
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion
Mutation detailsA targeting vector containing a FRT site flanked neomycin selection cassette and a loxP site was inserted downstream of exon 3 of the targeted gene, and another loxP site was inserted upstream of exon 3. Mutant mice were bred with ACT-FLPe mice (on a C57BL/6 congenic background) to remove the neomycin selection cassette. (J:101977)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tlr4 Mutation:  66 strains or lines available
Original:  J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017;
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
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