Nlgn2^tm1.1Sud
Targeted Allele Detail

Summary

• Symbol: Nlgn2^tm1.1Sud
• Name: neuroligin 2; targeted mutation 1.1, Thomas C Sudhof
• MGI ID: MGI:5567078
• Synonyms: FN2, Nlgn2^cKO
• Gene: Nlgn2 Location: Chr11:69713949-69728610 bp, - strand Genetic Position: Chr11, 42.89 cM
• Alliance: Nlgn2^tm1.1Sud page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:229887
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert a loxP site followed by a frt-flanked neomycin resistance (neo) cassette upstream of exon 3, and a second loxP site downstream of exon 5. Flp-mediated recombination removed the selection cassette and left exons 3 through 5 floxed. (J:229887)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nlgn2 Mutation: 34 strains or lines available

References

• Original: J:229887 Liang J, et al., Conditional neuroligin-2 knockout in adult medial prefrontal cortex links chronic changes in synaptic inhibition to cognitive impairments. Mol Psychiatry. 2015 Jul;20(7):850-9
• All: 16 reference(s)