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Nlgn2tm1.1Sud
Targeted Allele Detail
Nomenclature
Symbol: Nlgn2tm1.1Sud
Name: neuroligin 2; targeted mutation 1.1, Thomas C Sudhof
MGI ID: MGI:5567078
Synonyms: FN2, Nlgn2cKO
Gene: Nlgn2  Location: Chr11:69713949-69728610 bp, - strand  Genetic Position: Chr11, 42.89 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:229887
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6NTac
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA targeting vector was designed to insert a loxP site followed by a frt-flanked neomycin resistance (neo) cassette upstream of exon 3, and a second loxP site downstream of exon 5. Flp-mediated recombination removed the selection cassette and left exons 3 through 5 floxed. (J:229887)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nlgn2 Mutation:  24 strains or lines available
References
Original:  J:229887 Liang J, et al., Conditional neuroligin-2 knockout in adult medial prefrontal cortex links chronic changes in synaptic inhibition to cognitive impairments. Mol Psychiatry. 2015 Jul;20(7):850-9
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory