Nfe2l2^tm1.1Jgpi
Targeted Allele Detail

Summary

• Symbol: Nfe2l2^tm1.1Jgpi
• Name: nuclear factor, erythroid derived 2, like 2; targeted mutation 1.1, Jingbo Pi
• MGI ID: MGI:5566912
• Synonyms: Nrf2^LoxP
• Gene: Nfe2l2 Location: Chr2:75505857-75534985 bp, - strand Genetic Position: Chr2, 44.75 cM
• Alliance: Nfe2l2^tm1.1Jgpi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:208590
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted upstream of exon 5. An additional loxP site was inserted downstream of exon 5. Flp-mediated recombination removed the selection cassette. (J:208590)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nfe2l2 Mutation: 88 strains or lines available

References

• Original: J:208590 Xue P, et al., Adipose deficiency of Nrf2 in ob/ob mice results in severe metabolic syndrome. Diabetes. 2013 Mar;62(3):845-54
• All: 14 reference(s)