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Hsd11b1tm1.2Awhi
Targeted Allele Detail
Nomenclature
Symbol: Hsd11b1tm1.2Awhi
Name: hydroxysteroid 11-beta dehydrogenase 1; targeted mutation 1.1, Anne White
MGI ID: MGI:5566778
Gene: Hsd11b1  Location: Chr1:193221640-193264049 bp, - strand  Genetic Position: Chr1, 97.67 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:207713
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion
 
Mutation detailsExon 2 was flanked by loxP sites. Cre-mediated recombination removed the neomycin resistance cassette and left exon 2 floxed. (J:207713)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hsd11b1 Mutation:  28 strains or lines available
References
Original:  J:207713 Harno E, et al., 11beta-Hydroxysteroid dehydrogenase type 1 (11beta-HSD1) inhibitors still improve metabolic phenotype in male 11beta-HSD1 knockout mice suggesting off-target mechanisms. Endocrinology. 2013 Dec;154(12):4580-93
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory