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Transgene Detail
Symbol: Tg(UBC-GFP/HTT*84Q)22Shya
Name: transgene insertion 22, Shang-Hsun Yang
MGI ID: MGI:5565690
Synonyms: Ubi-G-HTT84Q
Transgene: Tg(UBC-GFP/HTT*84Q)22Shya  Location: unknown  
Strain of Origin:  FVB
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence, Reporter)
Mutation:    Insertion
Tg(UBC-GFP/HTT*84Q)22Shya expresses 1 gene
Mutation detailsThis transgene consists of exon 1 of the human HTT with the expansion of 84 CAG trinucleotide repeats, which encodes 153 amino acids, in the 3' end of the GFP gene, where the stop codon was removed and mutant HTT was ligated in frame, under the control of the human polyubiquitin-C promoter. Western blotting confirmed protein expression in the heart, liver, lung, spleen, kidney, muscle, and brain, with highest levels in the brain. GFP expression was confirmed in the brain. (J:209055)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:209055 Cheng PH, et al., Significantly differential diffusion of neuropathological aggregates in the brain of transgenic mice carrying N-terminal mutant huntingtin fused with green fluorescent protein. Brain Struct Funct. 2013 Jan;218(1):283-94
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory