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Flt3tm2.1Dosm
Targeted Allele Detail
Nomenclature
Symbol: Flt3tm2.1Dosm
Name: FMS-like tyrosine kinase 3; targeted mutation 2.1, Donald Small
MGI ID: MGI:5565506
Synonyms: FLT3/D835Y
Gene: Flt3  Location: Chr5:147267551-147337299 bp, - strand  Genetic Position: Chr5, 86.88 cM, cytoband G3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:205200
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Constitutively active)
Mutations:    Insertion, Single point mutation
 
Mutation detailsAn inverted floxed pgk-neo cassette was inserted in intron 19 and codon 838 was changed to TAC from TAT in exon 20 via homologous recombination. This results in a D838Y mutation corresponding to the D835Y mutation seen in patients with acute myeloid leukemia. Cre mediated recombination removed the neo cassette. (J:205200)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Flt3 Mutation:  52 strains or lines available
References
Original:  J:205200 Bailey E, et al., FLT3/D835Y mutation knock-in mice display less aggressive disease compared with FLT3/internal tandem duplication (ITD) mice. Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):21113-8
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/21/2021
MGI 6.17
The Jackson Laboratory