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Hmgb1tm1.1Ttg
Targeted Allele Detail
Nomenclature
Symbol: Hmgb1tm1.1Ttg
Name: high mobility group box 1; targeted mutation 1.1, Tadatsugu Taniguchi
MGI ID: MGI:5563518
Synonyms: Hmgb1f
Gene: Hmgb1  Location: Chr5:149046702-149053057 bp, - strand  Genetic Position: Chr5, 89.18 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:205499
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP-neo-loxP cassette was inserted upstream of exon 2 and a third loxP site was inserted downstream of exon 4. Cre-mediated recombination removed the neo cassette. (J:205499)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hmgb1 Mutation:  8 strains or lines available
References
Original:  J:205499 Yanai H, et al., Conditional ablation of HMGB1 in mice reveals its protective function against endotoxemia and bacterial infection. Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20699-704
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/31/2020
MGI 6.15
The Jackson Laboratory