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Pomt2tm1Sstr
Targeted Allele Detail
Nomenclature
Symbol: Pomt2tm1Sstr
Name: protein-O-mannosyltransferase 2; targeted mutation 1, Sabine Strahl
MGI ID: MGI:5563037
Gene: Pomt2  Location: Chr12:87106861-87147968 bp, - strand  Genetic Position: Chr12, 41.3 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:205502
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA genomic region including parts of exons 2 and 3 was replaced a neo cassette via homologous recombination. This results in a frameshift mutation after amino acid T100 and a premature stop after 4 additional amino acids. (J:205502)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pomt2 Mutation:  24 strains or lines available
References
Original:  J:205502 Lommel M, et al., Protein O-mannosylation is crucial for E-cadherin-mediated cell adhesion. Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):21024-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory