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Cpeb3tm1.2Yshu
Targeted Allele Detail
Nomenclature
Symbol: Cpeb3tm1.2Yshu
Name: cytoplasmic polyadenylation element binding protein 3; targeted mutation 1.2, Yi-Shuian Huang
MGI ID: MGI:5562642
Synonyms: CPEB3KO
Gene: Cpeb3  Location: Chr19:37021291-37208601 bp, - strand  Genetic Position: Chr19, 32.08 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:202741
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn FRT-flanked PGK-neo cassette is inserted into intron 1, followed by loxP-flanked exon 2. Flp- and Cre- mediated recombinase removed the neo cassette and exon 2, resulting in an alternative start and early stop in exon 3. Western blot analysis and immunostaining confirmed the absence of protein expression in coronal brain slices from homozygous mice. (J:202741)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cpeb3 Mutation:  19 strains or lines available
References
Original:  J:202741 Chao HW, et al., Deletion of CPEB3 Enhances Hippocampus-Dependent Memory via Increasing Expressions of PSD95 and NMDA Receptors. J Neurosci. 2013 Oct 23;33(43):17008-22
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/30/2020
MGI 6.15
The Jackson Laboratory