Cpeb3^tm1.2Yshu
Targeted Allele Detail

Summary

• Symbol: Cpeb3^tm1.2Yshu
• Name: cytoplasmic polyadenylation element binding protein 3; targeted mutation 1.2, Yi-Shuian Huang
• MGI ID: MGI:5562642
• Synonyms: CPEB3KO
• Gene: Cpeb3 Location: Chr19:36998691-37186000 bp, - strand Genetic Position: Chr19, 32.08 cM
• Alliance: Cpeb3^tm1.2Yshu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:202741
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT-flanked PGK-neo cassette is inserted into intron 1, followed by loxP-flanked exon 2. Flp- and Cre- mediated recombinase removed the neo cassette and exon 2, resulting in an alternative start and early stop in exon 3. Western blot analysis and immunostaining confirmed the absence of protein expression in coronal brain slices from homozygous mice. (J:202741)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cpeb3 Mutation: 35 strains or lines available

References

• Original: J:202741 Chao HW, et al., Deletion of CPEB3 Enhances Hippocampus-Dependent Memory via Increasing Expressions of PSD95 and NMDA Receptors. J Neurosci. 2013 Oct 23;33(43):17008-22
• All: 7 reference(s)