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Cadpstm1.2Tfr
Targeted Allele Detail
Nomenclature
Symbol: Cadpstm1.2Tfr
Name: Ca2+-dependent secretion activator; targeted mutation 1.2, Teiichi Furuichi
MGI ID: MGI:5562542
Synonyms: Caps-
Gene: Cadps  Location: Chr14:12372563-12823079 bp, - strand  Genetic Position: Chr14, 6.37 cM, cytoband A2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:204664
Parent Cell Line:  MS12 (ES Cell)
Strain of Origin:  C57BL/6NSlc
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 6 and an FRT-flanked neo cassette followed by another loxP site were inserted downstream of exon 6. The loxP-flanked exon 6 and neo cassette were removed by recombination. (J:204664)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cadps Mutation:  1 strain or line available
References
Original:  J:204664 Sadakata T, et al., CAPS1 deficiency perturbs dense-core vesicle trafficking and Golgi structure and reduces presynaptic release probability in the mouse brain. J Neurosci. 2013 Oct 30;33(44):17326-34
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/23/2020
MGI 6.15
The Jackson Laboratory