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Oprd1tm1.1Cgrf
Targeted Allele Detail
Nomenclature
Symbol: Oprd1tm1.1Cgrf
Name: opioid receptor, delta 1; targeted mutation 1.1, Claire Gaveriaux-Ruff
MGI ID: MGI:5562342
Synonyms: Oprd1fl
Gene: Oprd1  Location: Chr4:132110726-132144486 bp, - strand  Genetic Position: Chr4, 64.78 cM, cytoband D1-D3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:208176
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA floxed hygromycin resistance gene was inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 2. Cre-mediated recombination removed the selection cassette and left exon 2 floxed. (J:208176)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Oprd1 Mutation:  20 strains or lines available
References
Original:  J:208176 Gaveriaux-Ruff C, et al., Genetic ablation of delta opioid receptors in nociceptive sensory neurons increases chronic pain and abolishes opioid analgesia. Pain. 2011 Jun;152(6):1238-48
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory