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Gria1tm7Rlh
Targeted Allele Detail
Nomenclature
Symbol: Gria1tm7Rlh
Name: glutamate receptor, ionotropic, AMPA1 (alpha 1); targeted mutation 7, Richard L Huganir
MGI ID: MGI:5562310
Synonyms: GluA1DD, GluA1 S831D/S845D
Gene: Gria1  Location: Chr11:57011571-57330244 bp, + strand  Genetic Position: Chr11, 34.51 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:172128
Parent Cell Line:  MC1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsS831D (TCC to GAT) and S845D (AGC to GAC) serine to aspartate mutations were introduced to GluA1 (Gria1) cDNA using QuikChange site-directed mutagenesis (Stratagene). (J:172128)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gria1 Mutation:  11 strains or lines available
References
Original:  J:172128 Makino Y, et al., Enhanced synaptic plasticity in mice with phosphomimetic mutation of the GluA1 AMPA receptor. Proc Natl Acad Sci U S A. 2011 May 17;108(20):8450-5
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory