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Dp(16Ifnar1-Kcnj6)10Yey
Targeted Allele Detail
Summary
Symbol: Dp(16Ifnar1-Kcnj6)10Yey
Name: duplication, Chr 16, Y Eugene Yu 10
MGI ID: MGI:5561090
Synonyms: Dp(16)10Yey, Dp(16)4Yey, Dp(16Ifnar1-Kcnj6)4Yey, Ts6Yey
Gene: Dp(16Ifnar1-Kcnj6)10Yey  Location: unknown  Genetic Position: Chr16, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:208104
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1b-m2
Mutation
description
Allele Type:    Targeted
Mutations:    Duplication, Insertion
  Dp(16Ifnar1-Kcnj6)10Yey involves 87 genes/genome features (Gm22745, Gm23062, Gm22344 ...) View all
 
Mutation detailsThis duplication was generated by recombination between two MICER clone insertions (MHPn247l16 and MHPP54c08). The 3.7 Mb duplication spans Ifnar1 to Kcnj6, which contains 17 Hsa21 gene orthologs. The duplication retains the puromycin and neomycin resistance cassettes from the original MICER clones. (J:208104)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 6 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dp(16Ifnar1-Kcnj6)10Yey Mutation:  1 strain or line available
References
Original:  J:208104 Liu C, et al., Engineered chromosome-based genetic mapping establishes a 3.7 Mb critical genomic region for Down syndrome-associated heart defects in mice. Hum Genet. 2014 Jun;133(6):743-53
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory