b2b2736.2Clo
Chemically induced Allele Detail

Summary

• Symbol: b2b2736.2Clo
• Name: Mutant line 2736.2; Bench to Bassinet Program (B2B/CVDC), mutation 2736.2 Cecilia Lo
• MGI ID: MGI:5560812
• Gene: b2b2736.2Clo Location: unknown
• Alliance: b2b2736.2Clo page

Mutant 2736-002-1 (E14.5) exhibits apparent absence of the pulmonary artery with right aortic arch, confirmed as persistent truncus arterioles (PTA) by EFIC imaging

Show the 6 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: B2B/CvDC

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Undefined
• Mutation details: This ENU-induced mutation was isolated in a screen at the University of Pittsburgh. It is a subline of b2b2736Clo. (J:175213)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any b2b2736.2Clo Mutation: 1 strain or line available

Notes

Summative Diagnosis:

Mutant Type 2:
Cardiovascular Phenotype: Persistent truncus arteriosus (PTA, Type 1), atrioventricular ventricular septal defect (AVSD), right aortic arch (RAA), and aberrant left subclavian artery forming vascular ring
Noncardiovascular Phenotype: growth retardation, microphthalmia, syndactyly, micrognathia, cleft palate, hypoplastic kidneys, lungs, and thymus

Fyler Codes
The Fyler code developed by The Boston Children's Heart Foundation in Boston Children's Hospital provides a hierarchical clinical diagnosis of congenital cardiovascular defects and other disorders. These codes are used to delineate pathology in the mutant mouse models that parallel human disease and can be cross referenced to the International Pediatric and Congenital Cardiac Code (IPCCC) (http://www.ipccc.net/).

Fyler Code ID	Code Description
1100	Atrioventricular canal (endocardial cushion defect)
2700	Abnormal aortic arch
2760	Vascular ring
4906	Non-cardiac abnormality
0510	Truncus arteriosus type i
2720	Right aortic arch
2730	Aberrant left subclavian artery
4170	Hand and/or foot anomaly
4174	Syndactyly

References

• Original: J:175213 Lo C, Information submitted by the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program (B2B/CvDC). MGI Direct Data Submission (B2B/CvDC). 2011-09-12
• All: 2 reference(s)