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Hcn4tm1Nnka
Targeted Allele Detail
Summary
Symbol: Hcn4tm1Nnka
Name: hyperpolarization-activated, cyclic nucleotide-gated K+ 4; targeted mutation 1, Noriyuki Nakashima
MGI ID: MGI:5560747
Synonyms: HCN4-Tet, Hcn4tm1(tTA), HCN4tTA_TRE
Gene: Hcn4  Location: Chr9:58730695-58770458 bp, + strand  Genetic Position: Chr9, 31.8 cM, cytoband C
Alliance: Hcn4tm1Nnka page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:207953
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted
Mutation:    Insertion
 
Mutation detailsThe targeting construct introduced upstream of the translation start site a tetracycline transactivator, floxed neomycin resistance cassette, polyadenylation sequence and tetracycline response element with CMV promoter (teto5-CMV). In the absence of doxycycline, the endogenous gene is over-expressed. Doxycycline treatment reduces expression. (J:207953)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hcn4 Mutation:  38 strains or lines available
References
Original:  J:207953 Nakashima N, et al., Hyperpolarisation-activated cyclic nucleotide-gated channels regulate the spontaneous firing rate of olfactory receptor neurons and affect glomerular formation in mice. J Physiol. 2013 Apr 1;591(Pt 7):1749-69
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/22/2022
MGI 6.22
The Jackson Laboratory