Agxt2^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Agxt2^tm1Lex
• Name: alanine-glyoxylate aminotransferase 2; targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:5560668
• Gene: Agxt2 Location: Chr15:10358618-10410239 bp, + strand Genetic Position: Chr15, 5.35 cM
• Alliance: Agxt2^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:207876
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• The beta-geo and puromycin resistance cassette replaced exons 8 and 9. (J:207876)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Agxt2 Mutation: 30 strains or lines available

References

• Original: J:207876 Caplin B, et al., Alanine-glyoxylate aminotransferase-2 metabolizes endogenous methylarginines, regulates NO, and controls blood pressure. Arterioscler Thromb Vasc Biol. 2012 Dec;32(12):2892-900
• All: 1 reference(s)