Vkorc1^tm1.1Jobg
Targeted Allele Detail

Summary

• Symbol: Vkorc1^tm1.1Jobg
• Name: vitamin K epoxide reductase complex, subunit 1; targeted mutation 1.1, Johannes Oldenburg
• MGI ID: MGI:5560512
• Gene: Vkorc1 Location: Chr7:127492235-127494789 bp, - strand Genetic Position: Chr7, 69.81 cM
• Alliance: Vkorc1^tm1.1Jobg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:207884
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 2. Cre-mediated recombination removed the selection cassette and exon 2. Real-time quantitative PCR confirmed the absence of transcript expression in mouse embryonic fibroblasts. (J:207884)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vkorc1 Mutation: 6 strains or lines available

References

• Original: J:207884 Spohn G, et al., VKORC1 deficiency in mice causes early postnatal lethality due to severe bleeding. Thromb Haemost. 2009 Jun;101(6):1044-50
• All: 1 reference(s)