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Tg(PDGFB-LRRK2*G2019S)32Hlw
Transgene Detail
Summary
Symbol: Tg(PDGFB-LRRK2*G2019S)32Hlw
Name: transgene insertion 32, Hung-Li Wang
MGI ID: MGI:5559903
Synonyms: (G2019S) LRRK2
Transgene: Tg(PDGFB-LRRK2*G2019S)32Hlw  Location: unknown  
Alliance: Tg(PDGFB-LRRK2*G2019S)32Hlw page
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(PDGFB-LRRK2*G2019S)32Hlw expresses 1 gene
 
Mutation detailsThe human LRRK2 with the disease causing G2019S mutation with an HA tag on the C-terminus is under the control of the CMV enhancer and PDGF-beta chain promoter. Two lines were established, 32 and 51. This line contains 10 copies of the transgene. (J:204793)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:204793 Chen CY, et al., (G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD. Cell Death Differ. 2012 Oct;19(10):1623-33
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory