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Slc16a1tm2.1Lupel
Targeted Allele Detail
Nomenclature
Symbol: Slc16a1tm2.1Lupel
Name: solute carrier family 16 (monocarboxylic acid transporters), member 1; Targeted mutation 2.1, Luc Pellerin
MGI ID: MGI:5559460
Synonyms: Mct1LacZ, Slc16a1tm1.1Geno
Gene: Slc16a1  Location: Chr3:104638668-104658462 bp, + strand  Genetic Position: Chr3, 45.7 cM
Slc16a1tm2.1Lupel/Slc16a1+ mice exhibit decreased susceptibility to diet-induced obesity

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:205481
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn in frame insertion of a lacZ/neo cassette in exon 1 replaced a 640 bp segment following the endogenous start codon. Quantitative RT-PCR and western blot analysis detected reduced mRNA and protein expression in multiple tissues in heterozygous mice. LacZ expression was detected in the brain, heart and soleus muscle of heterozygous mice. (J:205481)
Generation of the Slc16a1tm2.1Lupel allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc16a1 Mutation:  2 strains or lines available
References
Original:  J:205481 Lengacher S, et al., Resistance to diet-induced obesity and associated metabolic perturbations in haploinsufficient monocarboxylate transporter 1 mice. PLoS One. 2013;8(12):e82505
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory