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Tg(Thy1-APPSweAut)A7Tiwa
Transgene Detail
Nomenclature
Symbol: Tg(Thy1-APPSweAut)A7Tiwa
Name: transgene insertion A7, Takeshi Iwatsubo
MGI ID: MGI:5559448
Synonyms: A7 APP Tg
Transgene: Tg(Thy1-APPSweAut)A7Tiwa  Location: unknown  
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Thy1-APPSweAut)A7Tiwa expresses 1 gene
 
Mutation detailsThis transgene expresses the human APP695 harboring the Swedish K670N and M671L (Swe) and the Austrian T714I (Aut) familial Alzheimer disease mutations in neurons under the control of the Thy1.2 promoter. Immunoblotting shows that expression of transgenic human APP proteins is about 1.4 fold that of endogenous murine App. (J:204270)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:204270 Yamada K, et al., Abeta immunotherapy: intracerebral sequestration of Abeta by an anti-Abeta monoclonal antibody 266 with high affinity to soluble Abeta. J Neurosci. 2009 Sep 9;29(36):11393-8
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/20/2015
MGI 5.21
The Jackson Laboratory