Meiob^tm1.1Ics
Targeted Allele Detail

Summary

• Symbol: Meiob^tm1.1Ics
• Name: meiosis specific with OB domains; targeted mutation 1.1, Mouse Clinical Institute
• MGI ID: MGI:5559212
• Gene: Meiob Location: Chr17:25023275-25058762 bp, + strand Genetic Position: Chr17, 12.53 cM, cytoband A3.3
• Alliance: Meiob^tm1.1Ics page

Reduced size of testes and ovaries in Meiob^tm1.1Ics/Meiob^tm1.1Ics mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:203426
• Parent Cell Line: BD10 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

Allele Type: Targeted (Null/knockout, Reporter) Mutations: Insertion, Intragenic deletion Mutation details: The coding sequence of exon 2 through 8 were replaced with an RFP gene and floxed neomycin resistance cassette. Cre-mediated recombination removed the selection cassette. RT-PCR confirmed the absence of transcript expression in testes. (J:203426)

Generation of the Meiob^tm1.1Ics allele

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Meiob Mutation: 28 strains or lines available

References

• Original: J:203426 Souquet B, et al., MEIOB targets single-strand DNA and is necessary for meiotic recombination. PLoS Genet. 2013;9(9):e1003784
• All: 2 reference(s)