Tg(tetO-COL4A3/Col4a3)#aJhm
Transgene Detail

Summary

• Symbol: Tg(tetO-COL4A3/Col4a3)#aJhm
• Name: transgene insertion #a, Jeffrey H Miner
• MGI ID: MGI:5559154
• Synonyms: T-Col4a3
• Transgene: Tg(tetO-COL4A3/Col4a3)#aJhm Location: unknown
• Alliance: Tg(tetO-COL4A3/Col4a3)#aJhm page

Transgene origin

• Strain of Origin: (C57BL/6J x CBA/J)F2

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Mutation details: The tetracycline regulatory element (tetO) drives inducible expression of a fusion of the human cDNA fragment encoding the first 133 amino acids and the mouse cDNA fragment encoding the remaining 1536 amino acids. Eight unnamed lines were generated. The pound symbol (#) is used when no line is specified and/or lines are pooled. Line #a represents the best expression line. Other lines exhibited novel expression in the intestine and spleen. (J:207595)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:207595 Lin X, et al., Feasibility of repairing glomerular basement membrane defects in alport syndrome. J Am Soc Nephrol. 2014 Apr;25(4):687-92
• All: 2 reference(s)