Tg(Nphs1-rtTA*3G)8Jhm
Transgene Detail

Summary

• Symbol: Tg(Nphs1-rtTA*3G)8Jhm
• Name: transgene insertion 8, Jeffrey H Miner
• MGI ID: MGI:5559153
• Synonyms: NEF-rtTA, NEFTA, Nphs1-rtTA-3G
• Transgene: Tg(Nphs1-rtTA*3G)8Jhm Location: unknown
• Alliance: Tg(Nphs1-rtTA*3G)8Jhm page

Transgene origin

• Strain of Origin: (C57BL/6J x CBA/J)F2

Transgene description

• Transgene Type: Transgenic (Transactivator)
• Mutation: Insertion
• Mutation details: The 4.1 kb mouse promoter drives podocyte-specific expression of a modified reverse tetracycline transactivator (rtTA*3G). Thirty-six lines were generated. Line 8 has the highest and most specific doxycycline-dependent expression in all podocytes. (J:207595)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:207595 Lin X, et al., Feasibility of repairing glomerular basement membrane defects in alport syndrome. J Am Soc Nephrol. 2014 Apr;25(4):687-92
• All: 6 reference(s)