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Tg(CMV-SALL4_iB)#Chai
Transgene Detail
Nomenclature
Symbol: Tg(CMV-SALL4_iB)#Chai
Name: transgene insertion, Li Chai
MGI ID: MGI:5558103
Transgene: Tg(CMV-SALL4_iB)#Chai  Location: unknown  
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(CMV-SALL4_iB)#Chai expresses 1 gene
 
Mutation detailsThe CMV promoter drives the expression of a cDNA encoding the 617 amino acids of human SALL4, isoform B. The B isoform lacks the region corresponding to amino acids 385 to 820 (3' part of exon 2) of the full-length A isoform and contains 3 zinc finger domains. Six lines were established (464, 504, 506, 507, 509, and 510) however, the pound symbol (#) is used when line is not specified and/or lines are pooled. (J:115037)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:115037 Ma Y, et al., SALL4, a novel oncogene, is constitutively expressed in human acute myeloid leukemia (AML) and induces AML in transgenic mice. Blood. 2006 Oct 15;108(8):2726-35
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/14/2021
MGI 6.17
The Jackson Laboratory