Il5tm1.1(icre)Lky
Targeted Allele Detail
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Symbol: |
Il5tm1.1(icre)Lky |
Name: |
interleukin 5; targeted mutation 1.1, Richard M Locksley |
MGI ID: |
MGI:5558083 |
Synonyms: |
Il5-, Il5R, Il5Red5, R5 |
Gene: |
Il5 Location: Chr11:53611621-53615930 bp, + strand Genetic Position: Chr11, 31.99 cM, cytoband A5/B1
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Alliance: |
Il5tm1.1(icre)Lky page
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Germline Transmission: |
Earliest citation of germline transmission:
J:206097
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Parent Cell Line: |
PRX-B6T (ES Cell)
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Strain of Origin: |
C57BL/6J
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Allele Type: |
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Targeted (Null/knockout, Recombinase, Reporter) |
Mutation: |
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Insertion
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Il5tm1.1(icre)Lky expression driven by
1 gene
Knock-in expression driven by:
Organism |
Driver Gene |
Note |
mouse |
Il5 (MGI:96557) |
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Mutation details: A targeting vector with a cassette composed of, (from 5' to 3'), a partial rabbit beta-globin exon 2-3 genomic sequence, the tdTomato coding sequence, an internal ribosomal entry site (IRES), a humanized cre recombinase sequence and a bovine growth hormone polyadenlyation signal was flanked by Il5 homology arms and linearized for homologous recombination in ES cells. The cassette was inserted at the transcriptional start ATG codon of the Il5 gene. Chimeric males were crossed to CMV-cre females to excise the neo marker, and then male offspring were bred to wild-type B6 females to remove the CMV-cre from the background. Mice express tdTomato and cre in cells where Il5 is expressed.
(J:206097)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Il5
(mouse)
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View phenotypes and curated references for all genotypes (concatenated display).
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Original: |
J:206097 Nussbaum JC, et al., Type 2 innate lymphoid cells control eosinophil homeostasis. Nature. 2013 Oct 10;502(7470):245-8 |
All: |
37 reference(s) |
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