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Targeted Allele Detail
Symbol: Il5tm1.1(icre)Lky
Name: interleukin 5; targeted mutation 1.1, Richard M Locksley
MGI ID: MGI:5558083
Synonyms: Il5R, Il5Red5, R5
Gene: Il5  Location: Chr11:53720794-53725103 bp, + strand  Genetic Position: Chr11, 31.99 cM, cytoband A5/B1
Germline Transmission:  Earliest citation of germline transmission: J:206097
Parent Cell Line:  PRX-B6T (ES Cell)
Strain of Origin:  C57BL/6J
Allele Type:    Targeted (Null/knockout, Recombinase)
Mutation:    Insertion
Mutation detailsA targeting vector with a cassette composed of, (from 5' to 3'), a partial rabbit beta-globin exon 2-3 genomic sequence, the tdTomato coding sequence, an internal ribosomal entry site (IRES), a humanized cre recombinase sequence and a bovine growth hormone polyadenlyation signal was flanked by Il5 homology arms and linearized for homologous recombination in ES cells. The cassette was inserted at the transcriptional start ATG codon of the Il5 gene. Chimeric males were crossed to CMV-cre females to excise the neo marker, and then male offspring were bred to wild-type B6 females to remove the CMV-cre from the background. Mice express tdTomato and cre in cells where Il5 is expressed. (J:206097)
 Tissue activity of this recombinase allele
Driver: Il5     Summary of all recombinase alleles driven by Il5.

View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Il5 Mutation:  24 strains or lines available
Original:  J:206097 Nussbaum JC, et al., Type 2 innate lymphoid cells control eosinophil homeostasis. Nature. 2013 Oct 10;502(7470):245-8
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
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