Gfi1b^tm1.1Haho
Targeted Allele Detail

Summary

• Symbol: Gfi1b^tm1.1Haho
• Name: growth factor independent 1B; targeted mutation 1.1, Hanno Hock
• MGI ID: MGI:5558052
• Synonyms: Gfi-1b^fl
• Gene: Gfi1b Location: Chr2:28499462-28511994 bp, - strand Genetic Position: Chr2, 19.38 cM
• Alliance: Gfi1b^tm1.1Haho page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:207446
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A targeting vector was designed to insert an FRT-flanked neomycin marker and a loxP site upstream of exon 2 of the Gfi1b gene and to insert a second loxP site between exons 5 and 6. Correctly targeted ES cells were treated with Flp to excise the neo resistance marker. (J:207446)

Generation of Gfi1b^tm1.1Haho.

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gfi1b Mutation: 20 strains or lines available

References

• Original: J:207446 Foudi A, et al., Distinct, strict requirements for Gfi-1b in adult bone marrow red cell and platelet generation. J Exp Med. 2014 May 5;211(5):909-27
• All: 1 reference(s)