About   Help   FAQ
Targeted Allele Detail
Symbol: Gt(ROSA)26Sortm1(Notch3*)Sfr
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Silvia Fre
MGI ID: MGI:5556106
Synonyms: R26-N3ICSAT
Gene: Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Germline Transmission:  Earliest citation of germline transmission: J:201985
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6NTac
Allele Type:    Targeted (Conditional ready, Constitutively active, Inserted expressed sequence, Reporter)
Mutation:    Insertion
Gt(ROSA)26Sortm1(Notch3*)Sfr expresses 1 gene
Mutation detailsA floxed stop cassette followed by a cDNA fragment encoding the mouse Notch3 intracellular domain (amino acids 1668 to 2318), IRES and sequence for YFP were inserted into intron 1. The Notch3 fragment acts as a constitutively active receptor. (J:201985)
Schematic of the Gt(ROSA)26Sortm1(Notch3*)Sfr allele
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  758 strains or lines available
Original:  J:201985 Lafkas D, et al., Notch3 marks clonogenic mammary luminal progenitor cells in vivo. J Cell Biol. 2013 Oct 14;203(1):47-56
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.19
The Jackson Laboratory