Clp1^tm2.2Pngr
Targeted Allele Detail

Summary

• Symbol: Clp1^tm2.2Pngr
• Name: CLP1, cleavage and polyadenylation factor I subunit; targeted mutation 2.2, Josef M Penninger
• MGI ID: MGI:5554923
• Gene: Clp1 Location: Chr2:84553466-84557631 bp, - strand Genetic Position: Chr2, 49.45 cM
• Alliance: Clp1^tm2.2Pngr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:196364
• Parent Cell Line: A9 (ES Cell)
• Strain of Origin: (C57BL/6 x 129P2/OlaHsd)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT- and loxP-flanked neomycin resistance cassette was inserted downstream of exon 2. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exon 2.

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Clp1 Mutation: 22 strains or lines available

References

• Original: J:196364 Hanada T, et al., CLP1 links tRNA metabolism to progressive motor-neuron loss. Nature. 2013 Mar 28;495(7442):474-80
• All: 1 reference(s)