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b2b2025.2Clo
Chemically induced Allele Detail
Nomenclature
Symbol: b2b2025.2Clo
Name: Mutant line 2025.2; Bench to Bassinet Program (B2B/CVDC), mutation 2025, subline 2 Cecilia Lo
MGI ID: MGI:5554445
Gene: b2b2025.2Clo  Location: unknown  
Mutant 2025-007-1 (E16.5) presents with malaligned great arteries, right aortic arch (RAA), and hypoplastic pulmonary artery

Show the 13 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  C57BL/6J
Project Collection: B2B/CvDC
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Undefined
 
Mutation detailsThis ENU-induced mutation was isolated in a screen at the University of Pittsburgh. It is a subline of b2b2025Clo. (J:175213) Additional incidental mutations were detected in sequencing for the causative mutation, b2b2025.2Clo, and may be present in stocks carrying this mutation.
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any b2b2025.2Clo Mutation:  1 strain or line available
Notes
Summative Diagnosis:
Cardiovascular phenotype: Double outlet right ventricle (DORV), hypoplastic pulmonary artery, atrioventricular septal defect (AVSD), right aortic arch (RAA), ventricular non-compaction, and aberrant left subclavian artery forming incomplete vascular ring
Noncardiovascular phenotype: Right microphthalmia and syndactyly

Fyler Codes
The Fyler code developed by The Boston Children's Heart Foundation in Boston Children's Hospital provides a hierarchical clinical diagnosis of congenital cardiovascular defects and other disorders. These codes are used to delineate pathology in the mutant mouse models that parallel human disease and can be cross referenced to the International Pediatric and Congenital Cardiac Code (IPCCC) (http://www.ipccc.net/).

Fyler Code ID Code Description
0600 Double outlet right ventricle
0606 DORV + AVSD (AV canal)
1100 Atrioventricular canal (endocardial cushion defect)
1802 Excessive myocardial trabeculation or noncompaction
2700 Abnormal aortic arch
2720 Right aortic arch
2730 Aberrant left subclavian artery
2760 Vascular ring
2966 Hypoplastic main pulmonary artery
4170 Hand and/or foot anomaly
4174 Syndactyly
4877 Microphthalmia

References
Original:  J:175213 Lo C, Information submitted by the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program (B2B/CvDC). MGI Direct Data Submission (B2B/CvDC). 2011-15;
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/16/2021
MGI 6.17
The Jackson Laboratory