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Tg(tetO-MAPT*K280,-luc)#Eman
Transgene Detail
Nomenclature
Symbol: Tg(tetO-MAPT*K280,-luc)#Eman
Name: transgene insertion, Eva-Maria Mandelkow
MGI ID: MGI:5554185
Synonyms: proaggregation, TauRDdeltaK, TauRD/deltaK280
Transgene: Tg(tetO-MAPT*K280,-luc)#Eman  Location: unknown  
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inducible, Inserted expressed sequence, Reporter)
Mutation:    Insertion
 
Tg(tetO-MAPT*K280,-luc)#Eman expresses 1 gene
 
Mutation detailsThe tetracycline response element with a bidirectional CMV promoter drives inducible expression of the four-repeat domain on human MAPT (TauRD; 244-372 aa) carrying the frontotemporal dementia and parkinsonism linked to chromosome 17 Lys280 deletion (deltaK280), and a luciferase gene. The Lys280 deletion accelerates aggregation of MAPT (Tau). (J:131379)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:131379 Mocanu MM, et al., The potential for beta-structure in the repeat domain of tau protein determines aggregation, synaptic decay, neuronal loss, and coassembly with endogenous Tau in inducible mouse models of tauopathy. J Neurosci. 2008 Jan 16;28(3):737-48
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/13/2015
MGI 5.21
The Jackson Laboratory