Nle1tm1.2Cota
Targeted Allele Detail
|
Symbol: |
Nle1tm1.2Cota |
Name: |
notchless homolog 1; targeted mutation 1.2, Michel Cohen-Tannoudji |
MGI ID: |
MGI:5553358 |
Synonyms: |
Nle1del, Nle1delta |
Gene: |
Nle1 Location: Chr11:82791594-82799237 bp, - strand Genetic Position: Chr11, 50.3 cM
|
Alliance: |
Nle1tm1.2Cota page
|
|
Germline Transmission: |
Earliest citation of germline transmission:
J:204063
|
Parent Cell Line: |
CK35 (ES Cell)
|
Strain of Origin: |
129S2/SvPas
|
|
Allele Type: |
|
Targeted (Null/knockout) |
Mutations: |
|
Insertion, Intragenic deletion
|
|
|
Mutation details: A loxP site was inserted upstream of exon 4. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 9. Flp-mediated recombination removed the resistance cassette. Cre-mediated recombination removed exons 4 through 9.
(J:204063)
|
|
Generation of the Nle1tm1.1Cota and Nle1tm1.2Cota alleles |
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
Carrying any Nle1 Mutation: |
27 strains or lines available
|
|
Original: |
J:204063 Le Bouteiller M, et al., Notchless-dependent ribosome synthesis is required for the maintenance of adult hematopoietic stem cells. J Exp Med. 2013 Oct 21;210(11):2351-69 |
All: |
1 reference(s) |
|