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Ightm1.1Vmd
Targeted Allele Detail
Summary
Symbol: Ightm1.1Vmd
Name: immunoglobulin heavy chain complex; targeted mutation 1.1, Vishva M Dixit
MGI ID: MGI:5553164
Synonyms: SmuKI
Gene: Igh  Location: Chr12:113222388-115973574 bp, - strand  Genetic Position: Chr12, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:201147
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe Switch epsilon region (the weakest switch region) was replaced with a floxed neomycin resistance cassette and the Switch mu region (the strongest switch region). Cre-mediated recombination removed the resistance cassette. (J:201147)
Generation of the Ightm1.1Vmd allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Igh Mutation:  43 strains or lines available
References
Original:  J:201147 Misaghi S, et al., Polyclonal hyper-IgE mouse model reveals mechanistic insights into antibody class switch recombination. Proc Natl Acad Sci U S A. 2013 Sep 24;110(39):15770-5
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory