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Pdpntm2.1Mlkn
Targeted Allele Detail
Summary
Symbol: Pdpntm2.1Mlkn
Name: podoplanin; targeted mutation 2.1, Mark L Kahn
MGI ID: MGI:5552845
Synonyms: Pdpnf
Gene: Pdpn  Location: Chr4:142994001-143026134 bp, - strand  Genetic Position: Chr4, 77.29 cM
Alliance: Pdpntm2.1Mlkn page
VEGF-C-and galectin-8-induced lymphangiogenesis is diminished in Pdpntm2.1Mlkn/Pdpntm2.1Mlkn Tg(CAG-cre/Esr1*)5Amc/0 mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:205423
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsExon 2 was floxed. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette inserted upstream of exon 2. (J:205423)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pdpn Mutation:  28 strains or lines available
References
Original:  J:205423 Herzog BH, et al., Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2. Nature. 2013 Oct 3;502(7469):105-9
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory