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Ccr2tm1.1(CCR2)Rodb
Targeted Allele Detail
Nomenclature
Symbol: Ccr2tm1.1(CCR2)Rodb
Name: chemokine (C-C motif) receptor 2; targeted mutation 1.1, Robert D Berahovich
MGI ID: MGI:5552734
Synonyms: hCCR2 KI
Gene: Ccr2  Location: Chr9:124101918-124109140 bp, + strand  Genetic Position: Chr9, 75.05 cM, cytoband F
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:203000
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe mouse coding region was replaced with the corresponding human coding sequence. Cre-mediated recombination removed the neomycin resistance cassette. (J:203000)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ccr2 Mutation:  23 strains or lines available
References
Original:  J:203000 Sullivan T, et al., CCR2 antagonist CCX140-B provides renal and glycemic benefits in diabetic transgenic human CCR2 knockin mice. Am J Physiol Renal Physiol. 2013 Nov;305(9):F1288-97
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory