Vangl2tm2.2Mdea
Targeted Allele Detail
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Symbol: |
Vangl2tm2.2Mdea |
Name: |
VANGL planar cell polarity 2; targeted mutation 2.2, Michael R Deans |
MGI ID: |
MGI:5551990 |
Synonyms: |
Vangl2deltaATG |
Gene: |
Vangl2 Location: Chr1:171828527-171856011 bp, - strand Genetic Position: Chr1, 79.54 cM
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Alliance: |
Vangl2tm2.2Mdea page
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Germline Transmission: |
Earliest citation of germline transmission:
J:201321
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Parent Cell Line: |
TC1/TC-1 (ES Cell)
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Strain of Origin: |
129S6/SvEvTac
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the resistance cassette. Cre-mediated recombination removed exons 2 and 3. Western blot analysis confirmed the absence of protein expression in the brain at E18.5.
(J:201321)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Vangl2 Mutation: |
34 strains or lines available
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Original: |
J:201321 Copley CO, et al., Postnatal refinement of auditory hair cell planar polarity deficits occurs in the absence of Vangl2. J Neurosci. 2013 Aug 28;33(35):14001-16 |
All: |
1 reference(s) |
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