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Vangl2tm2.1Mdea
Targeted Allele Detail
Nomenclature
Symbol: Vangl2tm2.1Mdea
Name: VANGL planar cell polarity 2; targeted mutation 2.1, Michael R Deans
MGI ID: MGI:5551989
Synonyms: Vangl2LoxP
Gene: Vangl2  Location: Chr1:172000960-172027318 bp, - strand  Genetic Position: Chr1, 79.54 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:201321
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the resistance cassette and left exons 2 and 3 floxed. (J:201321)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Vangl2 Mutation:  15 strains or lines available
References
Original:  J:201321 Copley CO, et al., Postnatal refinement of auditory hair cell planar polarity deficits occurs in the absence of Vangl2. J Neurosci. 2013 Aug 28;33(35):14001-16
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory