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Targeted Allele Detail
Symbol: Sbno2tm1.1Aki
Name: strawberry notch 2; targeted mutation 1.1, Shizuo Akira
MGI ID: MGI:5551983
Gene: Sbno2  Location: Chr10:80056992-80105571 bp, - strand  Genetic Position: Chr10, 39.72 cM
Osteopetrotic phenotype of 10 week old Sbno2tm1.1Aki/Sbno2tm1.1Aki mice

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:202853
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA loxP site was inserted upstream of exon 19. A floxed neomycin resistance cassette was inserted downstream of exon 25. Cre-mediated recombination removed exon 19 through 25 and the resistance cassette. RT-PCR confirmed the absence of transcript expression in derived macrophages. (J:202853)
Generation of the Sbno2tm1.1Aki allele
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sbno2 Mutation:  36 strains or lines available
Original:  J:202853 Maruyama K, et al., Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP. J Exp Med. 2013 Sep 23;210(10):1947-60
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory