Kdm6btm1.1Iwam
Targeted Allele Detail
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Symbol: |
Kdm6btm1.1Iwam |
Name: |
KDM1 lysine (K)-specific demethylase 6B; targeted mutation 1.1, Naoki Iwamori |
MGI ID: |
MGI:5551613 |
Synonyms: |
Jmjd3F, Jmjd3Floxed |
Gene: |
Kdm6b Location: Chr11:69289334-69304501 bp, - strand Genetic Position: Chr11, 42.6 cM
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Alliance: |
Kdm6btm1.1Iwam page
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Enlarged testes in Kdm6btm1.1Iwam/Kdm6btm1.2Iwam Tg(Stra8-icre)1Reb/0 males
Show the 1 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:206350
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Parent Cell Line: |
E14TG2a (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Conditional ready, No functional change) |
Mutation: |
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Insertion
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Mutation details: An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 14. An additional loxP site was inserted downstream of 21. Flp-mediated recombination removed the resistance cassette and left exons 14 through 21 floxed.
(J:206350)
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Generation of the Kdm6btm1Iwam, Kdm6btm1.1Iwam, and Kdm6btm1.2Iwam alleles |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Kdm6b Mutation: |
65 strains or lines available
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Original: |
J:206350 Iwamori N, et al., H3K27 demethylase, JMJD3, regulates fragmentation of spermatogonial cysts. PLoS One. 2013;8(8):e72689 |
All: |
6 reference(s) |
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