Glp1r^tm1.1Stof
Targeted Allele Detail

Summary

• Symbol: Glp1r^tm1.1Stof
• Name: glucagon-like peptide 1 receptor; targeted mutation 1.1, Doris Stoffers
• MGI ID: MGI:5551409
• Gene: Glp1r Location: Chr17:31120841-31155484 bp, + strand Genetic Position: Chr17, 15.8 cM
• Alliance: Glp1r^tm1.1Stof page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:206563
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 6. An additional loxP site was inserted downstream of exon 7. Flp-mediated recombination removed the neomycin resistance cassette. (J:206563)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Glp1r Mutation: 49 strains or lines available

References

• Original: J:206563 Wilson-Perez HE, et al., Vertical sleeve gastrectomy is effective in two genetic mouse models of glucagon-like Peptide 1 receptor deficiency. Diabetes. 2013 Jul;62(7):2380-5
• All: 16 reference(s)