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Tg(PDGFB-APPInd)F17Plhn
Transgene Detail
Nomenclature
Symbol: Tg(PDGFB-APPInd)F17Plhn
Name: transgene insertion F17, Pyung-Lim Han
MGI ID: MGI:5550581
Synonyms: Tg-betaCTF99
Transgene: Tg(PDGFB-APPInd)F17Plhn  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(PDGFB-APPInd)F17Plhn expresses 1 gene
 
Mutation detailsThis transgene consists of the platelet-derived growth factor beta promoter, the human APP signal sequence, the amyloid beta containing carboxy-terminal 99 amino acids of APP with the Indiana V717F mutation and the SV40 polyadenylation sequence. The Kozak sequence (GACC) was introduced in front of the ATG codon of the signal sequence to increase translation efficiency. 16 Founder lines were established. This is the highest expressing line. (J:107982)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:107982 Lee KW, et al., Progressive neuronal loss and behavioral impairments of transgenic C57BL/6 inbred mice expressing the carboxy terminus of amyloid precursor protein. Neurobiol Dis. 2006 Apr;22(1):10-24
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/25/2015
MGI 5.21
The Jackson Laboratory