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Targeted Allele Detail
Symbol: Il6ratm1.2Jcbr
Name: interleukin 6 receptor, alpha; targeted mutation 1.2, Jens Bruning
MGI ID: MGI:5550551
Gene: Il6ra  Location: Chr3:89869324-89913196 bp, - strand  Genetic Position: Chr3, 39.19 cM
Germline Transmission:  Earliest citation of germline transmission: J:188445
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsAn FRT-flanked neo cassette with a 5' loxP site was inserted upstream of exon 2, and an additional loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exons 2 and 3. Western blot analysis confirmed the absence of protein expression in the liver, spleen, thymus and lymph node. (J:188445)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Il6ra Mutation:  23 strains or lines available
Original:  J:188445 Wunderlich CM, et al., Cutting edge: Inhibition of IL-6 trans-signaling protects from malaria-induced lethality in mice. J Immunol. 2012 May 1;188(9):4141-4
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory