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Targeted Allele Detail
Symbol: Nacc1tm1.1Jlwa
Name: nucleus accumbens associated 1, BEN and BTB (POZ) domain containing; targeted mutation 1.1, Jianlong Wang
MGI ID: MGI:5547984
Gene: Nacc1  Location: Chr8:84670483-84687862 bp, - strand  Genetic Position: Chr8, 41.02 cM
Germline Transmission:  Earliest citation of germline transmission: J:203277
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA loxP site was inserted upstream of the coding sequence for the BTB/POZ domain (exon 2). A floxed neomycin resistance cassette was inserted downstream of exon 3. Cre-mediated recombination removed the neomycin resistance cassette, exon 2 and exon 3. Western blot analysis confirmed the absence of protein expression in chondrocytes. (J:203277)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 3 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nacc1 Mutation:  58 strains or lines available
Original:  J:203277 Yap KL, et al., Loss of NAC1 expression is associated with defective bony patterning in the murine vertebral axis. PLoS One. 2013;8(7):e69099
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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