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Targeted Allele Detail
Symbol: Myod1tm1.1(cre/ERT,TVA)Gcg
Name: myogenic differentiation 1; targeted mutation 1.1, Gerard C Grosveld
MGI ID: MGI:5547828
Synonyms: MyoDCE
Gene: Myod1  Location: Chr7:46376474-46379092 bp, + strand  Genetic Position: Chr7, 30.03 cM
Germline Transmission:  Earliest citation of germline transmission: J:205518
Parent Cell Line:  F12 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
Mutation detailsA targeting vector was designed to insert the sequence encoding cre/ERT (CreER), an IRES-TVA (avian leukosis virus receptor) element, a floxed tk-NEO selection cassette, and an IRES sequence into the ATG start codon of the Myod1 gene. The construct was electroporated into "129SvJ" derived F12 embryonic stem (ES) cells, which were transiently transfected with a Cre recombinase vector to remove the selection cassette. ES cells that had successfully undergone cre-mediated recombination and no longer retained the cassette were injected into C57BL/6 blastocysts. The resulting chimeric animals were crossed to C57BL/6 mice. (J:205518)
 Tissue activity of this recombinase allele
Driver: Myod1     Summary of all recombinase alleles driven by Myod1. Comparative matrix view of recombinase activities

View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Myod1 Mutation:  11 strains or lines available
Original:  J:205518 Blum JM, et al., Distinct and overlapping sarcoma subtypes initiated from muscle stem and progenitor cells. Cell Rep. 2013 Nov 27;5(4):933-40
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
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