Tnip1^tm1.2Ama
Targeted Allele Detail

Summary

• Symbol: Tnip1^tm1.2Ama
• Name: TNFAIP3 interacting protein 1; targeted mutation 1.2, Averil Ma
• MGI ID: MGI:5547505
• Synonyms: ABIN-1^fl
• Gene: Tnip1 Location: Chr11:54801611-54853743 bp, - strand Genetic Position: Chr11, 32.13 cM
• Alliance: Tnip1^tm1.2Ama page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:205446
• Parent Cell Line: PRX-B6T (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neomycin resistance cassette was inserted upstream of exon 12, and an additional loxP site was inserted downstream of exon 15. Cre-mediated recombination removed the neomycin resistance cassette and left exons 12 through 15 floxed. (J:205446)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnip1 Mutation: 55 strains or lines available

References

• Original: J:205446 Callahan JA, et al., Cutting edge: ABIN-1 protects against psoriasis by restricting MyD88 signals in dendritic cells. J Immunol. 2013 Jul 15;191(2):535-9
• All: 3 reference(s)