About   Help   FAQ
Tg(Msx2-rtTA)888Lma
Transgene Detail
Nomenclature
Symbol: Tg(Msx2-rtTA)888Lma
Name: transgene insertion 888, Liang Ma
MGI ID: MGI:5546504
Transgene: Tg(Msx2-rtTA)888Lma  Location: unknown  
Shortened and curly vibrissae, wavy body hairs, shortened forelimbs and interdigital webs in Tg(Msx2-rtTA)888Lma/? mice

Show the 1 phenotype image(s) involving this allele.

Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Transactivator)
Mutation:    Insertion
 
Mutation detailsThis transgene consists of a 187 kb BAC clone, RP24-512K19, containing the endogenous Msx2 locus and flanking sequences (134 kb upstream and 47 kb downstream of Msx2; accession number AC154808) and a modified rtTA gene that replaced part of the first exon right after the start codon, followed by a FRT-flanked neomycin cassette and polyA sequences and was made using a two-step recombineering strategy. Two founding lines were established, 885 and 888. Western blot analysis failed to detect any truncated or fusion Msx2 protein. This BAC clone contains six additional predicted genes, which may be overexpressed. (J:148502)
Generation of the Tg(Msx2-rtTA)888Lma and Tg(Msx2-rtTA)885Lma transgenes
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:148502 Lin C, et al., Construction and characterization of a doxycycline-inducible transgenic system in Msx2 expressing cells. Genesis. 2009 Apr 15;47(5):352-359
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/05/2019
MGI 6.14
The Jackson Laboratory