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Capn6tm1Hiso
Targeted Allele Detail
Summary
Symbol: Capn6tm1Hiso
Name: calpain 6; targeted mutation 1, Hiroyuki Sorimachi
MGI ID: MGI:5544425
Gene: Capn6  Location: ChrX:142585232-142610408 bp, - strand  Genetic Position: ChrX, 64.83 cM, cytoband F2
Alliance: Capn6tm1Hiso page
Diameter of tongue muscle fibers is larger in Capn6tm1Hiso/Capn6tm1Hiso mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:200747
Parent Cell Line:  G4 (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6NCrl)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA lacZ with a nuclear localization signal and flanked by a lox71 and a lox2272 site replaced exon 2 and was followed immediately by an inserted neomycin resistsance cassette. Absence of protein in E10.5 and E12.5 embryos was confirmed by Western blot analysis. (J:200747)
Generation of the Capn6tm1Hiso allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Capn6 Mutation:  7 strains or lines available
References
Original:  J:200747 Tonami K, et al., Calpain-6 deficiency promotes skeletal muscle development and regeneration. PLoS Genet. 2013 Aug;9(8):e1003668
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/22/2022
MGI 6.22
The Jackson Laboratory